Prakash J. Mathew, MD

Prakash J. Mathew, MD, MBA, FACS, FCPP, is a double board-certified, fellowship-trained plastic and reconstructive surgeon with expertise in microsurgical breast reconstruction, advanced oncologic reconstruction, and aesthetic/cosmetic surgery of the face, breast, and body. Dr. Mathew is a member of the Penn Medicine | Virtua Health Cancer Program and serves as an assistant professor of plastic surgery at the University of Pennsylvania School of Medicine.

A native of San Francisco, Dr. Mathew completed both his medical degree and MBA at the University of California, Irvine. He completed a general surgery residency at the University of Arizona, followed by plastic surgery training at the University of Miami’s Jackson Memorial Hospital and fellowship training in reconstructive microsurgery at the University of Pennsylvania. Dr. Mathew specializes in advanced breast reconstruction techniques, including DIEP flap and implant-based reconstruction. He is one of only a few surgeons nationwide offering the Resensation® technique, which enables nipple neurotization after nipple-sparing mastectomy. He specializes in nerve reconstruction and complex oncologic reconstruction. His clinical practice also includes aesthetic surgery, specializing in blepharoplasty, breast augmentation, breast reduction, abdominoplasty, and body contouring after massive weight loss. He also offers surgical treatment of lymphedema and lipedema, utilizing modern microsurgical and physiological techniques to improve function and quality of life.

Dr. Mathew has authored numerous peer-reviewed publications and textbook chapters and serves as a reviewer for leading journals, including Plastic & Reconstructive Surgery and Aesthetic Surgery Journal. Dr. Mathew is an active member of the American College of Surgeons, American Society of Plastic Surgeons, The Aesthetic Society, and the American Society of Reconstructive Microsurgery. Dr. Mathew is one of the only surgeons nationwide certified by both the American Board of Surgery and the American Board of Plastic Surgery and is a fellow of the American College of Surgeons and the College of Physicians of Philadelphia.

Patients overwhelmingly praise Dr. Mathew for his exceptional professionalism, skill, compassionate care, and attentive approach, often highlighting the warm, courteous treatment they receive from both him and his staff. Many commend his ability to clearly explain procedures, listen carefully to concerns, and make them feel supported throughout their medical journey. Outside of the operating room, Dr. Mathew enjoys alternating weekend visits to the Adventure Aquarium and Philadelphia Zoo with his wife and two daughters, exploring the region’s fine-dining scene, and playing basketball and golf.